Ischemic stroke as an initial presentation of primary bone marrow lymphoma

@#Various cancer types have been associated with cancer-related cerebral infarction. In this study, we describe the first case of cancer-related cerebral infarction in which the underlying disease was primary bone marrow lymphoma (PBML). A 79-year-old man presented with abruptly developed bilateral lower extremity weakness and confusion. Diffusion-weighted imaging on admission showed multiple cortical and subcortical embolic infarction lesions in multiple vascular territories. Diagnostic evaluations to determine the embolic source revealed no abnormalities. Laboratory testing demonstrated elevated D-dimer (2.59 μg/mL) but no other prothrombotic abnormalities. In suspicion of cancer-related stroke, we performed chest CT, abdomen CT, and FDG-PET to detect the hidden malignancy. Findings revealed no evidence of cancer; however, they did reveal signs of anemia (hemoglobin 9.0 g/dL). Bone marrow aspiration biopsy showed large atypical B cell involvement suggestive of high-grade B cell lymphoma. The patient was diagnosed with primary bone marrow diffuse large B-cell lymphoma initially presenting with ischemic stroke. Our case suggests that primary bone marrow cancer may be a candidate for the differential diagnosis of hidden malignancy in patients with suspected cancer-related stroke. Bone marrow biopsy may be essential for establishing an appropriate differential diagnosis in patients with abnormal hematologic findings.

Antineoplastic therapy administration: Nursing intervention in the relief of suffering / Administração de terapia antineoplásica: intervenção de enfermagem no alívio do sofrimento / Administración de terapia antineoplásica: Intervención de enfermería en el alivio del sufrimiento

ABSTRACT Objective: To identify the nursing interventions with potential to act on the suffering and to evaluate the results of the nursing intervention designed. Method: We used a multi method study. After the identification of the scientific evidence and having found the supporting theory, the intervention process to relieve the suffering of hospitalized patients was modeled using the methodology of qualitative research. Then, training conditions were created for the implementation of the intervention Chemotherapy Administration as an Individualized Nursing Intervention, with a Quasi Experimental, longitudinal piloting study. Results: The patients of the experimental group showed values of suffering lower than the control group . Having finished the pilot study, we would return to qualitative research to understand the variation of some data. Final Considerations: The use of mixed methods of investigations allowed the understanding of the different components of drug chemotherapy administration as an individualized nursing intervention.

RESUMO Objetivo: Identificar intervenções de enfermagem com o potencial de atuar sobre o sofrimento e avaliar os resultados da intervenção de enfermagem criada. Método: Uma abordagem de estudo multimétodo foi utilizada. Após identificar as evidências científicas e encontrar a teoria de apoio, o processo de intervenção para aliviar o sofrimento de pacientes hospitalizados foi modelado utilizando a metodologia da pesquisa qualitativa. Em seguida, foram criadas as condições de treinamento para a implementação da intervenção Administração da Quimioterapia como Intervenção de Enfermagem Individualizada, com estudo piloto quase experimental, longitudinal. Resultados: Os pacientes do grupo experimental apresentaram valores de sofrimento inferiores ao grupo controle. Após o término do estudo piloto, retornaríamos à pesquisa qualitativa para entender a variação de alguns dados. Considerações finais: O uso de métodos mistos de pesquisa permitiu a compreensão dos diferentes componentes da administração da quimioterapia medicamentosa como uma intervenção de enfermagem individualizada.

RESUMEN Objetivo: Identificar las intervenciones de enfermería con potencial para actuar sobre el sufrimiento y evaluar los resultados de la intervención de enfermería diseñada. Método: Utilizamos un estudio de varios métodos. Tras identificarse la evidencia científica y determinarse su fundamentación teórica, se modeló el proceso de intervención para aliviar el sufrimiento de los pacientes hospitalizados, aplicándose metodología cuantitativa. Posteriormente, se crearon las condiciones de capacitación para implementar la intervención Administración de Quimioterapia como una Intervención de Enfermería Individualizada, con un estudio piloto longitudinal cuasi -experimental. Resultados: Los pacientes del grupo experimental mostraron valores de sufrimiento inferiores a los del grupo control. Habiendo finalizado la prueba piloto, habríamos de retomar la investigación cualitativa para comprender la variación de algunos datos. Consideraciones finales: La aplicación de métodos mixtos de investigación permitió comprender los diferentes componentes de la administración de la quimioterapia farmacológica como una intervención de enfermería individualizada.